There is "no reason to believe" that Prince's death at the age of 57 was suicide, police have said.
The pop superstar, real name Prince Rogers Nelson, was found dead at his home in suburban Minneapolis, Minnesota, on Thursday.
Stunned fans have laid bouquets and purple balloons outside his home, as tributes poured in from across the world.
Giving an update on the latest in the police investigation into the singer-songwriter's death, Carver County Sheriff Jim Olson said there were no signs of trauma on Prince's body when he was found unresponsive in an elevator at his Paisley Park estate.
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Sheriff Olson refused to comment on reports the star had been taking a powerful painkiller before his death.
He said it was "still under investigation" whether foul play was involved.
Celebrity news website TMZ reported that Prince had overdosed on a drug called Percocet when his jet made an emergency landing in Atlanta, Georgia, on 15 April, six days before his death.
Quoting multiple sources, the website said he left hospital against the advice of doctors.
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Prince was taking the drug for a hip problem after having corrective surgery around six years ago, TMZ said.
He had cancelled two shows because of ill health in the run-up to his death.
A post-mortem examination was completed earlier on Friday, where information about Prince's "medical and social history" was gathered. the Midwest Medical Examiner's Office said.
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Prince's body has now been released to his family, although officials have said a cause of death may not be made public for weeks.
He was last seen at 8pm the night before his death when he was dropped off at his estate, Sheriff Olson said.
Staff members had been unable to reach the artist and he had been alone at the property, he added.
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